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April 24, 2008
PAT Tools for Accelerated Process Development and Improvement
“Just where am I supposed to look for information on mammalian cell culture so I can scale up our laboratory results to production quantities? No one publishes any or their “top secret” results so I’ll have to resort to trial-and-error techniques to find our optimal running conditions. I just know that our CEO will be breathing down my neck wanting results – yesterday. It looks like it will be a rough couple of months ahead.”
That situation is perhaps a fair cause for complaint today. Now; however, help is on the way. A recent article in BioProcess International magazine discusses how Emerson has joined up with Broadley-James and the University of Texas to develop and publish models for the optimization of mammalian cell cultures. Authors Greg McMillan, Trish Benton, Yang Zhang, and Michael Boudreau have published their methodology in, “PAT Tools for Accelerated Process Development and Improvement (873KB PDF).” By running just a few tests to identify model parameters, it will be possible to quickly find optimal operating conditions. These tests are ongoing but promise to produce tools and models for arriving at optimal cell manufacturing conditions in record time. Look for more results from these tests to be published soon.
Posted by Emerson's EasyDeltaV.com on April 24, 2008 | TrackBack (0)
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